Article
TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.
International journal of immunopathology and pharmacology - 1 Jan 2000
Ricciardolo F L M, Sorbello V, Silvestri M, Giacomelli M, Debenedetti V M G, Malerba M, Ciprandi G, Rossi G A, Rossi A, Bontempelli M
Abstract excerpt
Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms are detected in the protein coding sequence or in the promoter region thus influencing cytokine...
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