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Article

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.

British journal of cancer - 1 Apr 1999

Wang Z J, Churchman M, Campbell I G, Xu W H, Yan Z Y, McCluggage W G, Foulkes W D, Tomlinson I P

Abstract excerpt

Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients are at increased risk of benign and malignant ovarian tumours, particularly granulosa cell tumours....

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Source

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Identifiers

PMID: 10389980
DOI: 10.1038/sj.bjc.6690323
PMCID: PMC2363028

Genes

BRCA1
BRCA2
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.PMID 10389980Read ↗

Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p.Semantic proximity Read ↗

5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.Semantic proximity Read ↗

LKB1 somatic mutations in sporadic tumors.Semantic proximity Read ↗

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome.Semantic proximity Read ↗

An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers.Semantic proximity Read ↗

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.Semantic proximity Read ↗

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome.Semantic proximity Read ↗

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.Semantic proximity Read ↗

The molecular basis and clinical aspects of Peutz-Jeghers syndrome.Semantic proximity Read ↗

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.Semantic proximity Read ↗

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