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Article

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

Cancer research - 15 May 1998

Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe R A, Stenwig A E, Fosså S D, Salovaara R, Aaltonen L A

Abstract excerpt

Germ-line mutations in a serine/threonine kinase gene, LKB1, were recently shown to underlie Peutz-Jeghers syndrome (PJS), a hereditary disorder that predisposes to benign and malignant tumors of multiple organ systems. Most mutations that have been described thus far dramatically change the pred...

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PMID: 9605748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9605748-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.PMID 9605748Read ↗

LKB1 somatic mutations in sporadic tumors.Semantic proximity Read ↗

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.Semantic proximity Read ↗

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.Semantic proximity Read ↗

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.Semantic proximity Read ↗

De novo germline mutation in the serine–threonine kinase STK11/LKB1 gene associated with Peutz–Jeghers syndromeSemantic proximity Read ↗

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome.Semantic proximity Read ↗

An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.Semantic proximity Read ↗

Mutations of the STK11 gene in sporadic gastric carcinoma.Semantic proximity Read ↗

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