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Article

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

Cancer research - 15 May 1998

Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe R A, Stenwig A E, Fosså S D, Salovaara R, Aaltonen L A

Abstract excerpt

Germ-line mutations in a serine/threonine kinase gene, LKB1, were recently shown to underlie Peutz-Jeghers syndrome (PJS), a hereditary disorder that predisposes to benign and malignant tumors of multiple organ systems. Most mutations that have been described thus far dramatically change the predicted protein and are likely to be of an inactivating nature. This observation and a previous observation that the LKB1...

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PMID: 9605748

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Research trail→

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Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.PMID 9605748Read ↗

LKB1 somatic mutations in sporadic tumors.Semantic proximity Read ↗

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.Semantic proximity Read ↗

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.Semantic proximity Read ↗

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.Semantic proximity Read ↗

De novo germline mutation in the serine–threonine kinase STK11/LKB1 gene associated with Peutz–Jeghers syndromeSemantic proximity Read ↗

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome.Semantic proximity Read ↗

An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.Semantic proximity Read ↗

Mutations of the STK11 gene in sporadic gastric carcinoma.Semantic proximity Read ↗

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