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Article

Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p.

Clinical genetics - 1 May 2000

Chen J, Lindblom A

Abstract excerpt

The recently cloned STK11/LKB1 on chromosome 19p has been shown to be a new tumor suppressor gene. Mutations in the LKB1/STK11 gene on chromosome 19p account for most cases of Peutz-Jeghers syndrome (PJS), in which intestinal hamartomas are associated with elevated risks of several cancer types, including breast cancer. A previous study revealed that familial breast cancer is associated with loss of...

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Share to AMP-Activated Protein Kinase Kinases
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Share to Chromosomes, Human, Pair 19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

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Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 10852375
DOI: 10.1034/j.1399-0004.2000.570511.x

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p.PMID 10852375Read ↗

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