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Article

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

The Journal of investigative dermatology - 1 Apr 1999

Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W, Tomlinson I

Abstract excerpt

Germline mutations in the LKB1/STK11 gene cause characteristic hamartomas and freckling to develop in patients with Peutz-Jeghers syndrome (PJS). The hamartomas arise as a result of somatic "second hits" at LKB1/STK11 and therefore contain a neoplastic element. The origin of the pigmented lesions...

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Source

Identifiers

PMID: 10201537
DOI: 10.1046/j.1523-1747.1999.00551.x

Genes

STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10201537-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.PMID 10201537Read ↗

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Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

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