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Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2006

Haiman Christopher A, Stram Daniel O, Cheng Iona, Giorgi Elena E, Pooler Loreall, Penney Kathryn, Le Marchand Loïc, Henderson Brian E, Freedman Matthew L

Abstract excerpt

PTEN frequently shows loss of heterozygosity in breast and prostate cancers, and mutations in this gene are responsible for Cowden disease, a rare Mendelian syndrome that includes breast cancer as part of its phenotype. Thus, PTEN serves as a candidate susceptibility gene for both breast and prostate cancer risk. Whether common inherited variation (either coding or noncoding) at the PTEN locus contribute to...

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Identifiers

PMID: 16702386
DOI: 10.1158/1055-9965.EPI-05-0896

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.PMID 16702386Read ↗

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Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing.Semantic proximity Read ↗

Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.Semantic proximity Read ↗

Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations.Semantic proximity Read ↗

Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes.Semantic proximity Read ↗

Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.Semantic proximity Read ↗

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Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>MutationsSemantic proximity Read ↗

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