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Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.

Familial cancer - 1 Jan 2007

Guénard Frédéric, Labrie Yvan, Ouellette Geneviève, Beauparlant Charles Joly, Bessette Paul, Chiquette Jocelyne, Laframboise Rachel, Lépine Jean, Lespérance Bernard, Pichette Roxane, Plante Marie, Durocher Francine

Abstract excerpt

Cowden syndrome is a disease associated with an increase in breast cancer susceptibility. Alleles in PTEN and other breast cancer susceptibility genes would be responsible for approximately 25% of the familial component of breast cancer risk, BRCA1 and BRCA2 being the two major genes responsible for this inherited risk. In order to evaluate the proportion of high-risk French Canadian non-BRCA1/BRCA2...

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Identifiers

PMID: 17636424
DOI: 10.1007/s10689-007-9151-y

Genes

PTEN
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.PMID 17636424Read ↗

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