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Article

Polymorphisms in PTEN in breast cancer families.

Journal of medical genetics - 1 Feb 1999

Carroll B T, Couch F J, Rebbeck T R, Weber B L

Abstract excerpt

Germline mutations in PTEN are the underlying genetic defect in Cowden disease, which is associated with a lifetime risk of 25-50% of developing breast cancer. To investigate the role of PTEN in inherited breast cancer in the absence of manifestations of Cowden disease, we screened 177 unrelated subjects with breast cancer who also had a family history of breast cancer in at least one relative. We found no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Restriction Fragment Length

Share to PTEN Phosphohydrolase

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Source

Open in PubMed Open full text

Identifiers

PMID: 10051004
PMCID: PMC1734307

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Polymorphisms in PTEN in breast cancer families.PMID 10051004Read ↗

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Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.Semantic proximity Read ↗

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Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing.Semantic proximity Read ↗

Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer.Semantic proximity Read ↗

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PTEN Germline Mutations in Patients Initially Tested for Other Hereditary Cancer Syndromes: Would Use of Risk Assessment Tools Reduce Genetic Testing?Semantic proximity Read ↗

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