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Article

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

Journal of leukocyte biology - 1 Jul 2020

Knuplez Eva, Krier-Burris Rebecca, Cao Yun, Marsche Gunther, O'Sullivan Jeremy, Bochner Bruce S

Abstract excerpt

Eosinophils are important multifunctional granulocytes. When studying eosinophil function and its contribution to diseases, mouse models are often used. Mouse eosinophils selectively express sialic acid-binding immunoglobulin-like lectin (Siglec)-F. Its closest functional paralog on human eosinophils is Siglec-8. These Siglecs are being used to target eosinophils when exploring their mechanistic roles in disease...

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Identifiers

PMID: 32134149
DOI: 10.1002/JLB.3HI0120-381R
PMCID: PMC7585130

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