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Article

Loss of FancC Function Results in Decreased Hematopoietic Stem Cell Repopulating Ability

1 Jul 1999

Abstract excerpt

Fanconi anemia (FA) is a complex genetic disorder characterized by progressive bone marrow (BM) aplasia, chromosomal instability, and acquisition of malignancies, particularly myeloid leukemia. We used a murine model containing a disruption of the murine homologue of FANCC (FancC) to evaluate short- and long-term multilineage repopulating ability of FancC -/- cells in vivo. Competitive repopulation assays were...

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PMID: 10381491
DOI: 10.1182/blood.v94.1.1.413k03_1_8

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