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Article

Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs.

Chemistry & biology - 1 Jul 1999

Das A, Tang K S, Gopalakrishnan S, Waring M J, Tomasz M

Abstract excerpt

BACKGROUND: Mitomycin C (MC), a DNA cross-linking and alkylating agent, targets guanines in the m5CpG sequence with 2-3-fold preference over guanines in unmethylated CpG. Benzo[a]pyrenediolepoxide (BPDE) and several other aromatic carcinogens form guanine adducts with an identical selectivity for m5CpG, and in certain cancers G to T transversion mutation 'hotspots' in the p53 tumor suppressor gene are more...

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Identifiers

PMID: 10381403
DOI: 10.1016/s1074-5521(99)80064-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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