Article
Flanking base effects on the structural conformation of the (+)-trans-anti-benzo[a]pyrene diolepoxide adduct to N2-dG in sequence-defined oligonucleotides.
Carcinogenesis - 1 Dec 1994
Suh M, Jankowiak R, Ariese F, Mao B, Geacintov N E, Small G J
Abstract excerpt
Conformations of the trans adduct of (+)-anti-benzo[a]pyrene -7,8-dihydrodiol-9,10-epoxide (BPDE) to N2-guanine, the major stable DNA adduct of the environmental carcinogen benzo[a]pyrene, were studied as a function of flanking bases in single-stranded and in double-stranded oligonucleotides. Thr...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Base Sequence
- Benzo(a)pyrene
- Benzopyrenes
- Cold Temperature
- DNA Adducts
- DNA Damage
- Electrophoresis, Polyacrylamide Gel
- Guanine
- Molecular Conformation
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Nucleic Acid Conformation
- Oligonucleotides