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Article

Flanking base effects on the structural conformation of the (+)-trans-anti-benzo[a]pyrene diolepoxide adduct to N2-dG in sequence-defined oligonucleotides.

Carcinogenesis - 1 Dec 1994

Suh M, Jankowiak R, Ariese F, Mao B, Geacintov N E, Small G J

Abstract excerpt

Conformations of the trans adduct of (+)-anti-benzo[a]pyrene -7,8-dihydrodiol-9,10-epoxide (BPDE) to N2-guanine, the major stable DNA adduct of the environmental carcinogen benzo[a]pyrene, were studied as a function of flanking bases in single-stranded and in double-stranded oligonucleotides. Three 11mer oligonucleotides d(CTAT-G1G2G3TATC) were synthesized containing the (+)-trans-anti-BPDE adduct at one specific...

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PMID: 8001252
DOI: 10.1093/carcin/15.12.2891

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AGA
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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