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Article

Covalent binding of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: molecular structures, induced mutations and biological consequences.

Biophysical chemistry - 1 Apr 1994

Jernström B, Gräslund A

Abstract excerpt

Optical spectroscopic techniques have been used to characterize adducts formed upon reaction of the (+)- and (-)-enantiomers of 7R,8S-dihydroxy 9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) to DNA or synthetic oligonucleotides. The reaction yields preferentially adducts in which the exocyclic aminogroup of deoxyguanosine is bound to the C10 position of the diol epoxide either cis (BPDEc-N2-G adduct)...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Animals
DNA
Humans
Magnetic Resonance Spectroscopy
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8018817
DOI: 10.1016/0301-4622(93)e0087-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8018817-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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