Article
Neuroligins determine synapse maturation and function.
Neuron - 21 Sept 2006
Varoqueaux Frédérique, Aramuni Gayane, Rawson Randi L, Mohrmann Ralf, Missler Markus, Gottmann Kurt, Zhang Weiqi, Südhof Thomas C, Brose Nils
Abstract excerpt
Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that...
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