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Article

Establishment of Tsc2‑deficient rat embryonic stem cells.

International journal of oncology - 1 May 2015

Ito Yoshitaka, Kawano Haruna, Kanai Fumio, Nakamura Eri, Tada Norihiro, Takai Setsuo, Horie Shigeo, Arai Hajime, Kobayashi Toshiyuki, Hino Okio

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by TSC1 or TSC2 mutations. TSC causes the development of tumors in various organs such as the brain, skin, kidney, lung, and heart. The protein complex TSC1/2 has been reported to have an inhibitory function on mammalian target of rapamycin complex 1 (mTORC1). Treatment with mammalian target of rapamycin (mTOR) inhibitors has demonstrated...

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Source

Identifiers

PMID: 25738543
DOI: 10.3892/ijo.2015.2913

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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