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Article

Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis.

The Journal of experimental medicine - 21 Jun 1999

Wilkinson R J, Patel P, Llewelyn M, Hirsch C S, Pasvol G, Snounou G, Davidson R N, Toossi Z

Abstract excerpt

Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1beta and its antagonist, IL-1Ra (IL-1 receptor agonist), are strongly induced by M. tuberculosis and are encoded by polymorphic genes. The induction of both IL-1Ra mRNA and secreted protein by M. tuberculosis in IL-1Ra allele...

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Source

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Identifiers

PMID: 10377182
DOI: 10.1084/jem.189.12.1863
PMCID: PMC2192963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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