Article
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers.
Pharmacogenetics - 1 Oct 1992
Rautio A, Kraul H, Kojo A, Salmela E, Pelkonen O
Abstract excerpt
A test designed to estimate the extent and rate of formation of 7-hydroxycoumarin by measuring the urinary excretion of the metabolite in humans after administering 5 mg coumarin was developed. Coumarin was rapidly metabolized after oral administration and more than 95% of the 7OHC formed was exc...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Coumarins
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 Enzyme System
- Female
- Genetic Variation
- Humans
- Hydroxylation
- Kinetics
- Male
- Middle Aged
- Mixed Function Oxygenases
- Reference Values
- Reproducibility of Results
- Umbelliferones