Article
Foamy virus integration.
Journal of virology - 1 Mar 2004
Juretzek Thomas, Holm Teresa, Gärtner Kathleen, Kanzler Sylvia, Lindemann Dirk, Herchenröder Ottmar, Picard-Maureau Marcus, Rammling Matthias, Heinkelein Martin, Rethwilm Axel
Abstract excerpt
It had been suggested that during integration of spumaretroviruses (foamy viruses) the right (U5) end of the cDNA is processed, while the left (U3) remains uncleaved. We confirmed this hypothesis by sequencing two-long terminal repeat (LTR) circle junctions of unintegrated DNA. Based on an infectious foamy virus molecular clone, a set of constructs harboring mutations at the 5' end of the U3 region in the 3' LTR...
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