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Article

Expression of the IAPs in multidrug resistant tumor cells

1 Jan 2004

Abstract excerpt

We have investigated the expression of the IAPs (inhibitory of apoptosis proteins) in the human HL-60 leukemia and in its multidrug resistant, P-glycoprotein (P-gp) over-expressing variant, HL-60R. HL-60R exhibits resistance to apoptosis induced from P-gp substrate drugs and also from other triggers (cisplatin, TNF-alpha, Fas ligation, TRAIL, IFN-gamma and serum starvation) not related to the multidrug...

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PMID: 14654915
DOI: 10.3892/or.11.1.133

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