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Article

CPT-11-induced cell death in leukemic cells is not affected by the MDR phenotype.

Leukemia research - 1 Mar 2003

Silva Karina L, Vasconcelos Flavia C, Marques-Santos Luis Fernando, Kwee Jolie K, Maia Raquel C

Abstract excerpt

CPT-11 is a topoisomerase I (Topo I) inhibitor which was initially described as active in multi-drug resistance (MDR) tumors. The MDR phenomenon is characterized by the overexpression of efflux pumps which are able to extrude a range of drugs non-related chemical or functionally. In this work, we treated leukemic cells with CPT-11 300 microM at 24h and compared its cytotoxicity with the activity of efflux pumps...

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PMID: 12537977
DOI: 10.1016/s0145-2126(02)00094-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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