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Article

Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis.

Journal of hepatology - 1 May 2007

Karlsen Tom H, Boberg Kirsten Muri, Olsson Marita, Sun Ji-Yao, Senitzer David, Bergquist Annika, Schrumpf Erik, Thorsby Erik, Lie Benedicte A

Abstract excerpt

BACKGROUND/AIMS: Combinations of killer immunoglobulin-like receptors (KIRs) and HLA class I ligands that reduce natural killer (NK) cell inhibition have been shown to increase risk for autoimmune diseases. We aimed to clarify to what extent such combinations influence susceptibility to primary sclerosing cholangitis (PSC). METHODS: Three hundred and sixty-five Scandinavian PSC patients and 368 healthy controls...

Topics

Adolescent
Adult
Aged
Autoimmune Diseases
Child
Cholangitis, Sclerosing
Gene Frequency
Genetic Predisposition to Disease
HLA-A Antigens
HLA-B Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-B7 Antigen

HLA-B8 Antigen

HLA-C Antigens

HLA-DR3 Antigen

HLA-DR6 Antigen

HLA-DRB1 Chains

Haplotypes

Humans

Source

Identifiers

PMID: 17383044
DOI: 10.1016/j.jhep.2007.01.032

Genes

MICA

Provenance

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Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis.PMID 17383044Read ↗

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.Semantic proximity Read ↗

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.Semantic proximity Read ↗

Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune HepatitisSemantic proximity Read ↗

Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms.Semantic proximity Read ↗

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KIRs and autoimmune disease: studies in systemic lupus erythematosus and scleroderma.Semantic proximity Read ↗

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.Semantic proximity Read ↗

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Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis.Semantic proximity Read ↗

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