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Article

A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.

Nature genetics - 1 Jun 1999

Knight J C, Udalova I, Hill A V, Greenwood B M, Peshu N, Marsh K, Kwiatkowski D

Abstract excerpt

Genetic variation in cytokine promoter regions is postulated to influence susceptibility to infection, but the molecular mechanisms by which such polymorphisms might affect gene regulation are unknown. Through systematic DNA footprinting of the TNF (encoding tumour necrosis factor, TNF) promoter region, we have identified a single nucleotide polymorphism (SNP) that causes the helix-turn-helix transcription factor...

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Source

Identifiers

PMID: 10369255
DOI: 10.1038/9649

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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