Article
The evolution and diversity of TNF block haplotypes in European, Asian and Australian Aboriginal populations.
Genes and immunity - 1 Oct 2009
Valente F P, Tan C R T, Temple S E, Phipps M, Witt C S, Kaur G, Gut I, McGinn S, Allcock R J N, Chew C S N, Price P
Abstract excerpt
The region spanning the tumour necrosis factor (TNF) cluster in the human major histocompatibility complex is implicated in susceptibility to immunopathological disease, but ethnic differences and linkage disequilibrium have hampered identification of critical polymorphisms. Here, we investigate Europeans, Asians (Bidayuh, Chinese, Indian, Jehai, Malay, Temuan) and Australian Aborigines to provide a framework for...
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