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Article

Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers.

Cell proliferation - 1 Aug 2008

Burum-Auensen E, DeAngelis P M, Schjølberg A R, Røislien J, Mjåland O, Clausen O P F

Abstract excerpt

OBJECTIVES: The majority of solid human malignancies demonstrate DNA aneuploidy as a consequence of chromosomal instability. We wanted to investigate whether Aurora A, Aurora B, BUB1B and Mad2 were associated with the development of aneuploidy in colorectal adenocarcinomas as suggested by several in vitro studies, and if their protein levels were related to alterations at the corresponding chromosomal loci....

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Identifiers

PMID: 18699967
DOI: 10.1111/j.1365-2184.2008.00539.x
PMCID: PMC6496857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers.PMID 18699967Read ↗

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