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Article

Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer.

Carcinogenesis - 1 Jan 2007

Mondal Gourish, Sengupta Shiladitya, Panda Chinmoy K, Gollin Susanne M, Saunders William S, Roychoudhury Susanta

Abstract excerpt

Defects in the spindle assembly checkpoint are thought to be responsible for an increased rate of aneuploidization during tumorigenesis. Despite a plethora of information on the correlation between BUB-MAD gene expression levels and defects in the spindle checkpoint, very little is known about alteration of another important spindle checkpoint protein, Cdc20, in human cancer and its role in tumor aneuploidy. We...

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Share to Anaphase-Promoting Complex-Cyclosome
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Source

Identifiers

PMID: 16777988
DOI: 10.1093/carcin/bgl100

Genes

CDC20
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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