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Article

Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint.

Mutation research - 15 Oct 2005

Kim Han-Soo, Park Kyung Hwa, Kim Sun A, Wen Jing, Park Seung Woo, Park Byungkyu, Gham Chang-Woo, Hyung Woo Jin, Noh Sung Hoon, Kim Ho Kun, Song Si Young

Abstract excerpt

Since the underlying mechanism for the high incidence of aneuploidy in gastric cancer has not clarified, we screened 49 gastric cancers and five gastric cancer cell lines for mutations in the mitotic spindle checkpoint genes, Bub1 and Mad2, and we analyzed the functional consequences of these mutations. The presence of mutations in Bub1 and Mad2 coding sequences was primarily detected by RT-PCR-SSCP and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16112690
DOI: 10.1016/j.mrfmmm.2005.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint.PMID 16112690Read ↗

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