Article
Mutant p53: epigenetic mutator of the T-cell receptor via induction of methylation.
Molecular carcinogenesis - 1 Jun 1999
Iwamoto K S, Mizuno T, Seyama T, Kyoizumi S
Abstract excerpt
The mechanism and effects of epigenetic alterations in human carcinogenesis are not well understood, except that cancers often have alterations in the methylation status of their genomes. Additionally, human cancers, including aggressive T-cell leukemias and lymphomas, have a high frequency of p53 mutations, particularly missense mutations, which raises the possibility of gain-of-new-function proteins, but the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.