Article
Mechanically Driven Contour-Length Adjustment in Rat Cardiac Titin’s Unique N2B Sequence
11 Jun 1999
Abstract excerpt
The giant elastic protein titin is largely responsible for passive forces in cardiac myocytes. A number of different titin isoforms with distinctly different structural elements within their central I-band region are expressed in human myocardium. Their coexpression has so far prevented an understanding of the respective contributions of the isoforms to myocardial elasticity. Using isoform-specific antibodies, we...
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