Article
Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.
Developmental biology - 1 Jun 1999
Lele Z, Hartson S D, Martin C C, Whitesell L, Matts R L, Krone P H
Abstract excerpt
Members of the Hsp90 family of molecular chaperones play important roles in allowing some intracellular signaling molecules and transcription factors to reach and maintain functionally active conformations. In the present study, we have utilized the specific Hsp90-binding agent, geldanamycin, to examine the requirement for Hsp90 during zebrafish development. We show that geldanamycin interacts with both the alpha...
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