Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the role of Shh signaling in axial defects produced by ethanol exposure

23 Feb 2009

Abstract excerpt

BACKGROUND: The phenotype of embryos exposed to ethanol is complex and likely due to multiple alterations in developmental pathways. We have previously demonstrated that Sonic hedgehog signaling (Shh-s) was reduced in both chicken and zebrafish embryos when exposed to ethanol. METHODS: There are many tissues affected by embryonic ethanol exposure, and in this article we explore the development of axial tissues,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Prenatal Substance Exposure Effects
Share to TGF-β signaling in diseases
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19235835
DOI: 10.1002/bdra.20564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the role of Shh signaling in axial defects produced by ethanol exposurePMID 19235835Read ↗

The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development.Semantic proximity Read ↗

Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathwaySemantic proximity Read ↗

Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposureSemantic proximity Read ↗

Xenopus embryos to study fetal alcohol syndrome, a model for environmental teratogenesisSemantic proximity Read ↗

Ethanol down-regulates gastrula gene expression and cell movement, causing symptoms of foetal alcohol spectrum disordersSemantic proximity Read ↗

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.Semantic proximity Read ↗

Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol‐induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorderSemantic proximity Read ↗

Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia.Semantic proximity Read ↗

Zebrafish as a Model for Fetal Alcohol Spectrum DisordersSemantic proximity Read ↗

Ethanol exposure affects cell movement during gastrulation and induces split axes in zebrafish embryos.Semantic proximity Read ↗

Gene-environment interactions characterized by single embryo transcriptomicsSemantic proximity Read ↗

Bone Morphogenetic Protein signaling pathway – ethanol interactions disrupt palate formation independent of <i>gata3</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.