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Article

Dendritic cell-T-cell interactions support coreceptor-independent human immunodeficiency virus type 1 transmission in the human genital tract.

Journal of virology - 1 Jul 1999

Hladik F, Lentz G, Akridge R E, Peterson G, Kelley H, McElroy A, McElrath M J

Abstract excerpt

Worldwide, human immunodeficiency virus (HIV) is transmitted predominantly by heterosexual contact. Here, we investigate for the first time, by examining mononuclear cells obtained from cervicovaginal tissue, the mechanisms whereby HIV type 1 (HIV-1) directly targets cells from the human genital tract. In contrast to earlier findings in mucosal models such as human skin, we demonstrate that the majority of T...

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Topics

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Share to Cervix Uteri
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genitalia, Female

Share to Leukocytes, Mononuclear

Share to Mucous Membrane

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Vagina

Source

Open in PubMed Open full text

Identifiers

PMID: 10364335
DOI: 10.1128/JVI.73.7.5833-5842.1999
PMCID: PMC112644

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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