Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells.

doi:10.1038/s41467-021-22375-x

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Article

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells.

Nature communications - 12 Apr 2021

Rhodes Jake W, Botting Rachel A, Bertram Kirstie M, Vine Erica E, Rana Hafsa, Baharlou Heeva, Vegh Peter, O'Neil Thomas R, Ashhurst Anneliese S, Fletcher James, Parnell Grant P, Graham J Dinny, Nasr Najla, Lim Jake J K, Barnouti Laith, Haertsch Peter, Gosselink Martijn P, Di Re Angelina, Reza Faizur, Ctercteko Grahame, Jenkins Gregory J, Brooks Andrew J, Patrick Ellis, Byrne Scott N, Hunter Eric, Haniffa Muzlifah A, Cunningham Anthony L, Harman Andrew N

Abstract excerpt

Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be strongly associated with HIV transmission, here we examine the role of sub-epithelial MNPs which are present in a...

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PMID: 33846309
DOI: 10.1038/s41467-021-22375-x
PMCID: PMC8042121

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