Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.

Mucosal immunology - 1 Jul 2013

Ganor Y, Zhou Z, Bodo J, Tudor D, Leibowitch J, Mathez D, Schmitt A, Vacher-Lavenu M-C, Revol M, Bomsel M

Abstract excerpt

The penile urethra is routinely targeted by sexually transmitted bacterial and viral pathogens, and also represents a probable site for HIV type-1 (HIV-1) entry. Yet, the mechanisms of urethral HIV-1 transmission are unknown. To describe the initial steps of penile HIV-1 entry, we obtained whole penile tissues from individuals undergoing elective gender reassignment and developed ex vivo polarized explants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to HIV Envelope Protein gp41

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin A

Share to In Vitro Techniques

Share to Macrophages

Share to Mucous Membrane

Share to Receptors, HIV

Source

Identifiers

PMID: 23187317
DOI: 10.1038/mi.2012.116

Genes

CCL2
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.PMID 23187317Read ↗

Barriers of Mucosal Entry of HIV/SIVSemantic proximity Read ↗

Influence of Common Mucosal Co‐Factors on HIV Infection in the Female Genital TractSemantic proximity Read ↗

Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1Semantic proximity Read ↗

The rectal mucosal immune environment and HIV susceptibility among young men who have sex with menSemantic proximity Read ↗

Role of the epithelium in human papillomavirus and human immunodeficiency virus infections in the female genital tractSemantic proximity Read ↗

HIV-1 replicates and persists in vaginal epithelial dendritic cellsSemantic proximity Read ↗

<scp>HIV</scp>‐1 Vaginal Transmission: Cell‐Free or Cell‐Associated Virus?Semantic proximity Read ↗

Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques.Semantic proximity Read ↗

The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4+ CCR5+ Cells and Has Features of an Inflamed Epidermal BarrierSemantic proximity Read ↗

The Role of the Foreskin in Male Circumcision: An Evidence‐Based ReviewSemantic proximity Read ↗

Potential for virus endogenization in humans through testicular germ cell infection: the case of HIVSemantic proximity Read ↗

Defining the Interaction of HIV-1 with the Mucosal Barriers of the Female Reproductive TractSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.