Article
Genetic and nongenetic factors influencing plasma homocysteine levels in patients with ischemic cerebrovascular disease and in healthy control subjects.
The Journal of laboratory and clinical medicine - 1 Jun 1999
Lalouschek W, Aull S, Serles W, Schnider P, Mannhalter C, Lang T, Deecke L, Zeiler K
Abstract excerpt
Moderately elevated plasma homocysteine levels have been established as an independent risk factor for atherosclerosis and its complications, including cerebrovascular disease. A common mutation (C677T) in the gene encoding for the enzyme methylenetetrahydrofolate reductase (MTHFR) has been linked to increased plasma homocysteine levels in homozygous carriers, particularly in the presence of low folate levels....
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