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Article

Guanosine triphosphatase stimulation of oncogenic Ras mutants.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999

Ahmadian M R, Zor T, Vogt D, Kabsch W, Selinger Z, Wittinghofer A, Scheffzek K

Abstract excerpt

Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reason behind the oncogenicity of most Gly12/Gln61 mutations, thus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10359839
DOI: 10.1073/pnas.96.12.7065
PMCID: PMC22057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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