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Article

Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate.

Biochemistry - 18 Nov 2014

Khrenova Maria G, Mironov Vladimir A, Grigorenko Bella L, Nemukhin Alexander V

Abstract excerpt

Cancer-associated point mutations in Ras, in particular, at glycine 12 and glycine 13, affect the normal cycle between inactive GDP-bound and active GTP-bound states. In this work, the role of G12V and G13V replacements in the GAP-stimulated intrinsic GTP hydrolysis reaction in Ras is studied usi...

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Share to GTP-Binding Protein alpha Subunits, G12-G13

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Identifiers

PMID: 25339142
DOI: 10.1021/bi5011333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25339142-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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