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Article

Biased TCR repertoire in HIV-1-infected patients due to clonal expansion of HIV-1-reverse transcriptase-specific CTL clones.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1999

Kolowos W, Schmitt M, Herrman M, Harrer E, Löw P, Kalden J R, Harrer T

Abstract excerpt

To study whether an expansion of HIV-1-specific CTL is contributing to the skewed TCR repertoire in HIV-1-infection, we characterized the TCR usage of CTL clones specific for a conserved epitope in HIV-1 reverse transcriptase (RT/476-484). CTL clones from three HIV-1-infected patients displayed highly similar TCR usage and used the identical Vbeta6.1 and Valpha2.5 gene segments. CTL clones from two patients...

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Share to Cytotoxicity, Immunologic
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to HIV Reverse Transcriptase

Share to Oligopeptides

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 10358208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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