Article
Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.
Blood - 22 Jul 2010
Meyer-Olson Dirk, Simons Brenna C, Conrad Joseph A, Smith Rita M, Barnett Louise, Lorey Shelly L, Duncan Coley B, Ramalingam Ramesh, Kalams Spyros A
Abstract excerpt
Flexibility of the HIV-specific T-cell receptor repertoire is a hallmark of HIV-1 infection. Altered differentiation of HIV-specific CD45RO(+)/CCR7(-) (TemRO) CD8(+) effector-memory T cells into CD45RA(+)/CCR7(-) (TemRA) CD8(+) effector-memory T cells as well as increased expression of the senescence marker CD57 has been frequently observed HIV-1 infection, but the structural relationship between clonal expansion...
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