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Article

Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.

The EMBO journal - 1 Jun 1999

Sun Z Y, Dötsch V, Kim M, Li J, Reinherz E L, Wagner G

Abstract excerpt

A general strategy is presented here for producing glycan-free forms of glycoproteins without loss of function by employing apolar-to-polar mutations of surface residues in functionally irrelevant epitopes. The success of this structure-based approach was demonstrated through the expression in Escherichia coli of a soluble 11 kDa adhesion domain extracted from the heavily glycosylated 55 kDa human CD58...

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Identifiers

PMID: 10357807
DOI: 10.1093/emboj/18.11.2941
PMCID: PMC1171376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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