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Article

Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain.

Biochimica et biophysica acta - 31 May 1999

Wally J, Kica G, Zhang Y, Ericsson T, Connors L H, Benson M D, Liepnieks J J, Murray J, Skinner M, Comenzo R L

Abstract excerpt

Current concepts regarding the association between immunoglobulin (Ig) light chain structure and AL amyloidosis (AL) emphasize Ig variable region amino acid substitutions because the majority of light chain amyloid fibrils that have been sequenced contain amino termini of the variable region with only small amounts of the constant region. In this report, we describe a patient with rapidly progressive AL whose...

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Source

Identifiers

PMID: 10354514
DOI: 10.1016/s0925-4439(99)00019-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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