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Article

Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.

The American journal of pathology - 1 Dec 1999

Vidal R, Goñi F, Stevens F, Aucouturier P, Kumar A, Frangione B, Ghiso J, Gallo G

Abstract excerpt

Light chain deposition disease (LCDD) and light chain amyloidosis (AL) are disorders of monoclonal immunoglobulin deposition in which normally soluble serum precursors form insoluble deposits in tissues. A common feature in both is the clonal proliferation of B-cells that produce pathogenic light chains. However, the deposits in LCDD differ from those in AL in that they are ultrastructurally granular rather than...

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Source

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Identifiers

PMID: 10595931
DOI: 10.1016/s0002-9440(10)65520-4
PMCID: PMC1866929

Genes

GLA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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