Article
Prognostic significance of allelic imbalances on chromosome 9p in stage I non-small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 1999
Tomizawa Y, Adachi J, Kohno T, Hamada K, Saito R, Noguchi M, Matsuno Y, Hirohashi S, Yamaguchi N, Yokota J
Abstract excerpt
Loss of heterozygosity (LOH) on chromosomes 2q, 9p, 18q, and 22q frequently occurs in advanced non-small cell lung carcinoma (NSCLC). The association of p53 mutations with prognosis is still unclear in NSCLC. Therefore, we investigated the prognostic significance of allelic imbalances (AI) on these chromosomes and p53 mutations in 108 cases of stage I NSCLC by PCR amplification of polymorphic dinucleotide...
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