Article
Suicide gene therapy in head and neck carcinoma cells: an in vitro study.
International journal of molecular medicine - 1 Apr 2011
Schmidt Marianne, Gruensfelder Petra, Roller Jeanette, Hagen Rudolf
Abstract excerpt
The aim of gene therapy includes the tight spatial and temporal control of transgenic expression. There are several approaches concerning the externally inducible gene promoters used for the control of suicide genes. We have tested the mifepristone-dependent system GeneSwitch to regulate the expression of a deletion mutant of Pseudomonas exotoxin A in the hypopharyngeal carcinoma cell line, FADU. The GeneSwitch...
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