Article
Hemoglobin C in transgenic mice: effect of HbC expression from founders to full mouse globin knockouts.
Blood cells, molecules & diseases - 1 Aug 2000
Fabry M E, Romero J R, Suzuka S M, Gilman J G, Feeling-Taylor A, Odunusi E, Factor S M, Bouhassira E E, Lawrence C, Nagel R L
Abstract excerpt
When present in the homozygous form, hemoglobin C (HbC, CC disease) increases red cell density, a feature that is the major factor underlying the pathology in patients with SC disease (Fabry et al., JCI 70, 1315, 1982). The basis for the increased red cell density has not yet been fully defined. We have generated a HbC mouse in which the most successful founder expresses 56% human alpha and 34% human beta(C). We...
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