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Article

The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms.

Rheumatology (Oxford, England) - 1 Jan 1999

Layton M A, Jones P W, Alldersea J E, Strange R C, Fryer A A, Dawes P T, Mattey D L

Abstract excerpt

OBJECTIVES: To investigate whether the therapeutic response of rheumatoid arthritis (RA) patients to D-penicillamine is associated with polymorphisms in genes of the glutathione S-transferase (GST) supergene family. METHODS: Disease activity in 81 patients with RA treated with D-penicillamine monotherapy was assessed using the Stoke Index, a validated index of disease activity, prior to treatment and at 6 months....

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Source

Identifiers

PMID: 10334681
DOI: 10.1093/rheumatology/38.1.43

Genes

GSTM1
GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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