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Article

Fluorescence polarization in homogeneous nucleic acid analysis.

Genome research - 1 May 1999

Chen X, Levine L, Kwok P Y

Abstract excerpt

A new method for DNA diagnostics based on template-directed primer extension and detection by fluorescence polarization is described. In this method, amplified genomic DNA containing a polymorphic locus is incubated with oligonucleotide primers (designed to hybridize to the DNA template adjacent to the polymorphic site) in the presence of allele-specific dye-labeled dideoxyribonucleoside triphosphates and a...

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Identifiers

PMID: 10330129
PMCID: PMC310763

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