Article
An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy.
Molecular genetics and metabolism - 1 Aug 2001
Lucock M, Daskalakis I, Hinkins M, Yates Z
Abstract excerpt
The effect of four polymorphic genes of folate-dependent methionine biosynthesis have been investigated in mothers affected by a neural tube defect pregnancy (NTD) and matched controls. The influence of the various genotypes on total red cell 5-methyl-H(4)folate,5,10-methenyl-H(4)folate, and 5-formyl-H(4)folate is reported, as is the effect on homocysteine and radioassay folate in both serum and red cells. All of...
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