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Article

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007

Yu Shengqiang, Hackmann Karl, Gao Jiangang, Gao Jianggang, He Xiaobing, Piontek Klaus, García-González Miguel A, García González Miguel A, Menezes Luis F, Xu Hangxue, Germino Gregory G, Zuo Jian, Qian Feng

Abstract excerpt

Polycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption of its function causes cystogenesis in human autosomal dominant polycystic kidney disease. We have previously shown that recombinant human PC1 is cis-autoproteolytically cleaved at the G protein-coupled receptor proteolytic site domain. To investigate the role of cleavage in vivo, we generated by gene targeting a Pkd1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18003909
DOI: 10.1073/pnas.0708217104
PMCID: PMC2141838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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