Article
ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.
Molecular and cellular biology - 15 Apr 2017
Li Feixue, Fu Guoquan, Liu Ying, Miao Xiaoping, Li Yan, Yang Xueqin, Zhang Xiaoyun, Yu Dongliang, Gan Lin, Qiu Mengsheng, Chen Yiping, Zhang Ze, Zhang Zunyi
Abstract excerpt
Mandibular patterning information initially resides in the epithelium during development. However, how transcriptional regulation of epithelium-derived signaling controls morphogenesis of the mandible remains elusive. Using ShhCre to target the mandibular epithelium, we ablated transcription factor Islet1, resulting in a distally truncated mandible via unbalanced cell apoptosis and decreased cell proliferation in...
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