Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.

Journal of neurophysiology - 1 Jul 2010

Samuels Ivy S, Sturgill Gwen M, Grossman Gregory H, Rayborn Mary E, Hollyfield Joe G, Peachey Neal S

Abstract excerpt

Mutations in genes expressed in the retinal pigment epithelium (RPE) underlie a number of human inherited retinal disorders that manifest with photoreceptor degeneration. Because light-evoked responses of the RPE are generated secondary to rod photoreceptor activity, RPE response reductions observed in human patients or animal models may simply reflect decreased photoreceptor input. The purpose of this study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electroretinography
Share to Intermediate Filament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Peripherins

Share to Retinal Degeneration

Share to Retinal Pigment Epithelium

Share to Retinal Rod Photoreceptor Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 20484527
DOI: 10.1152/jn.00088.2010
PMCID: PMC2904221

Genes

RPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.PMID 20484527Read ↗

Light-evoked responses of the mouse retinal pigment epithelium.Semantic proximity Read ↗

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Semantic proximity Read ↗

Visual system hyperexcitability and compromised V1 receptive field properties in early-stage retinitis pigmentosa in miceSemantic proximity Read ↗

Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.Semantic proximity Read ↗

[Slow retinal degeneration in a mouse model: morphological and functional aspects].Semantic proximity Read ↗

Structural and functional phenotyping in the cone-specific photoreceptor function loss 1 (cpfl1) mouse mutant - a model of cone dystrophies.Semantic proximity Read ↗

Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.Semantic proximity Read ↗

Characterization of an ocular photopigment capable of driving pupillary constriction in mice.Semantic proximity Read ↗

Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene.Semantic proximity Read ↗

A Bietti Crystalline Dystrophy Mouse Model Shows Increased Sensitivity to Light-Induced Injury.Semantic proximity Read ↗

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degenerationSemantic proximity Read ↗

Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night visionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.